Madhumithra Subramanian Karthikesh, Ph.D.

Microscopist

Contact Info

Email:

madhusubkar@ku.edu

Research —

Areas of Interest: Ionizing Radiation Acoustic Imaging, Ultrasound and Photoacoustic Imaging, Microscopy, Immunohistochemistry, Histological Techniques, Cellular and Molecular Imaging, Image Analysis, Translational Research, Science Communication, Mentorship

Dr. Subramanian Karthikesh’s doctoral research focuses on developing integrated laser/ultrasound platforms for diagnostic and therapeutic applications for melanoma, age-related macular degeneration, and stroke. Dr. Subramanian Karthikesh was a postdoctoral research fellow at the University of Michigan, where her work focused on clinical translation of ionizing radiation acoustic imaging (IRAI) for real-time visualization of radiation dose delivery during radiotherapy. Dr. Subramanian Karthikesh has expertise in digital image processing and statistical analysis, with applications spanning microscopy, preclinical imaging, and clinical data interpretation. Dr. Subramanian Karthikesh is also an invited reviewer for multiple scientific journals and actively promotes collaborative and translational research.

Selected Publications —

2025

Huang, Y., Oraiqat, I., Litzenberg, D., Karthikesh, M. S., Tichacek, C., Gonzalez, G., Xu, Z., Dykstra, S., Li, B., Hadley, S., Moros, E. G., Zhang, M., Carson, P. L., Cuneo, K. C., Wang, X., El Naqa, I., Zhang, W. 2025. Ionizing radiation acoustic and ultrasound dual-modality imaging for visualization of dose on anatomical structures during radiotherapy. Photoacoustics, 44:100742. URL: https://doi.org/10.1016/j.pacs.2025.100742

2024

Karthikesh, M. S., Martinez-Rivera, N., Rosa-Molinar, E., Wang, X., & Yang, X. 2024. Ultrasound-assisted laser therapy for selective removal of melanoma cells. Experimental Biology and Medicine, 249. URL: https://doi.org/10.3389/ebm.2024.10096
Chang, K.-W.*, Karthikesh, M. S.*, Zhu, Y., Hudson, H. M., Barbay, S., Bundy, D., Guggenmos, D. J., Frost, S., Nudo, R. J., Wang, X., Yang, X. 2023. Photoacoustic imaging of squirrel monkey cortical responses induced by peripheral mechanical stimulation. Journal of Biophotonics, e202300347. URL: https://doi.org/10.1002/jbio.202300347

2022

Karthikesh, M. S., Wu, S., Singh, R., Paulus, Y., Wang, X., & Yang, X. 2022. Effect of photo-mediated ultrasound therapy on nitric oxide and prostacyclin from endothelial cells. Applied Sciences, 12(5), 2617. URL: https://doi.org/10.3390/app12052617

2021

Karthikesh, M. S., & Yang, X. 2021. The effect of ultrasound cavitation on endothelial cells. Experimental Biology and Medicine (Maywood, NJ), 246(6), 700–706.
URL: https://doi.org/10.1177/1535370220982301

2020

Karthikesh, M. S., & Yang, X. 2020. Photoacoustic image-guided interventions. Experimental Biology and Medicine (Maywood, NJ), 245(4), 330–337.
URL: https://doi.org/10.1177/1535370219889323

2018

Madhumithra, S. K., Balashanmugam, P., MosaChristas, K., Tamil Selvi, A., Subashini, R. 2018. In vitro cytotoxicity of biosynthesized gold nanoparticles from shells of Pistacia vera L. International Journal of Applied Pharmaceutics, 10(4), 162–167.
URL: https://doi.org/10.22159/ijap.2018v10i4.27154